Pure Encapsulations® Niacinamide does not cause vasodilation (“flush”) associated with niacin. Research indicates that niacinamide may support healthy glucose metabolism and protect pancreatic beta-cell function. In a meta-analysis of 10 randomized controlled trials, niacinamide supplementation promoted healthy C-peptide levels, insulin metabolism and beta-cell function. In another study, niacinamide helped maintain healthy C-peptide levels and glucose metabolism. Niacinamide also promotes joint mobility and comfort. In a 12-week randomized double-blind trial involving 72 subjects, niacinamide provided statistically significant support for joint flexibility. Alpha-lipoic acid is included to offer synergistic support for healthy glucose balance and metabolic function.